Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) CLIA Kit | CECR1 clia kit

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) CLIA Kit

Cat. Num. AAA2000547

• Gene Names: CECR1; PAN; ADA2; ADGF; IDGFL; SNEDS
• Reactivity: Human
• Synonyms: Cat Eye Syndrome Chromosome Region; Candidate 1 (CECR1); Human Cat Eye Syndrome Chromosome Region; Candidate 1 (CECR1) CLIA Kit; IDGFL; ADGF; ADA2; Cat Eye Syndrome Critical Region Protein 1; CECR1 clia kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1).; No significant cross-reactivity or interference between Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) and analogues was observed.
• Sequence Length: 511

• Assay Type: Double-antibody Sandwich
• Samples: Serum, Plasma and Other Biological Fluids
• Detection Range: 27.4-20,000pg/mL
• Sensitivity: < 9.5pg/mL
• Application: Chemiluminescent immunoassay for Antigen Detection.
• Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) were tested 20 times on one plate, respectively.
• Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) were tested on 3 different plates, 8 replicates in each plate.
• CV(%) =: SD/meanX100
• Intra-Assay: CV<10%
• Inter-Assay: CV<12%
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. ; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for CECR1 clia kit

The microplate provided in this kit has been pre-coated with an antibody specific to Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) level in the sample or standard.;

Product Categories/Family for CECR1 clia kit

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 30704990
• NCBI GeneID: 51816
• UniProt Accession #: Q9NZK5; Q6ICF1; Q86UB6; Q8NCJ2; Q96K41; A8K9H4
• Molecular Weight: 30,668 Da
• NCBI Official Full Name: Cat eye syndrome chromosome region, candidate 1
• NCBI Official Synonym Full Names: cat eye syndrome chromosome region, candidate 1
• NCBI Official Symbol: CECR1
• NCBI Official Synonym Symbols: PAN; ADA2; ADGF; IDGFL; SNEDS
• NCBI Protein Information: adenosine deaminase CECR1
• UniProt Protein Name: Adenosine deaminase CECR1
• Protein Family: Adenosine deaminase
• UniProt Gene Name: CECR1
• UniProt Synonym Gene Names: ADA2; ADGF; IDGFL
• UniProt Entry Name: CECR1_HUMAN

NCBI Description

This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

CECR1: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Belongs to the adenosine and AMP deaminases family. ADGF subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.4; Secreted; Hydrolase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q11.2

Cellular Component: extracellular space; cytosol

Molecular Function: adenosine deaminase activity; heparin binding; proteoglycan binding; protein homodimerization activity; growth factor activity; zinc ion binding; adenosine receptor binding

Biological Process: adenosine catabolic process; multicellular organismal development; hypoxanthine salvage; inosine biosynthetic process

Disease: Polyarteritis Nodosa, Childhood-onset; Sneddon Syndrome