T-lymphocyte Activation Antigen CD86 Active Protein | Cd86 active protein
Recombinant Rat T-lymphocyte Activation Antigen CD86 Protein
Gene Names
Cd86; B7-2
Purity
>95% as determined by SDS-PAGE
Synonyms
T-lymphocyte Activation Antigen CD86; Recombinant Rat T-lymphocyte Activation Antigen CD86 Protein; T-lymphocyte activation antigen CD86; Activation B7-2 antigen; CD86; Cd86 active protein
Host
Human Cells
Purity/Purification
>95% as determined by SDS-PAGE
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
Sequence
Vla29-Lys247
Sequence Length
313
Species
Rat
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fusion Tag
C-6His
Activity
Measured by its binding ability in a functional ELISA. Immobilized rat CD86 at 2 mug/ml (100 mul/well) can bind mouse CD28 with a linear ranger of 6.4-160 ng/ml.
Preparation and Storage
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for Cd86 active protein
Protein Construction: Recombinant Rat T-lymphocyte Activation Antigen CD86 is produced by our mammalian expression system and the target gene encoding Vla29-Lys247 is expressed with a 6His tag at the C-terminus.
Background: T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Background: T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Mass: 25.9kDa
Actual Protein Molecular Mass: 35-55kDa
Actual Protein Molecular Mass: 35-55kDa
NCBI Official Full Name
T-lymphocyte activation antigen CD86
NCBI Official Synonym Full Names
CD86 molecule
NCBI Official Symbol
Cd86
NCBI Official Synonym Symbols
B7-2
NCBI Protein Information
T-lymphocyte activation antigen CD86
UniProt Protein Name
CD86 molecule
Protein Family
UniProt Gene Name
Cd86
NCBI Description
plays a role in T-cell activation and proliferation [RGD, Feb 2006]
Research Articles on Cd86
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Product Notes
The Cd86 cd86 (Catalog #AAA2557625) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Vla29-Lys2 47. It is sometimes possible for the material contained within the vial of "T-lymphocyte Activation Antigen CD86, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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