SDS-Page
(Recombinant protein Human R-spondin-3/RSPO3 was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 70 kDa.)
R-spondin-3/RSPO3 Active Protein | RSPO3 active protein
Recombinant Human R-spondin-3/RSPO3 Protein
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant protein Human R-spondin-3/RSPO3 was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 70 kDa.)
SDS-Page
(Recombinant protein Human R-spondin-3/RSPO3 was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 70 kDa.)
Background: This protein belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
Uniprot Description
R-spondin-3: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Belongs to the R-spondin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6q22.33
Cellular Component: extracellular space; extracellular region
Molecular Function: heparin binding; G-protein-coupled receptor binding; frizzled binding; receptor binding
Biological Process: Wnt receptor signaling pathway through beta-catenin
Research Articles on RSPO3
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Product Notes
The RSPO3 rspo3 (Catalog #AAA9139872) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: QNASRGRRQR RMHPNVSQGC QGGCATCSDY NGCLSCKPRL FFALERIGMK QIGVCLSSCP SGYYGTRYPD INKCTKCKAD CDTCFNKNFC TKCKSGFYLH LGKCLDNCPE GLEANNHTME CVSIVHCEVS EWNPWSPCTK KGKTCGFKRG TETRVREIIQ HPSAKGNLCP PTNETRKCTV QRKKCQKGER GKKGRERKRK KPNKGESKEA IPDSKSLESS KEIPEQRENK QQQKKRKVQD KQKSVSVSTV H. It is sometimes possible for the material contained within the vial of "R-spondin-3/RSPO3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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