XCL1 / XCL2 Blocking Peptide | XCL1 blocking peptide

XCL1 / XCL2 Immunizing Peptide

Cat. Num. AAA425333

• Gene Names: XCL1; LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• Reactivity: Human
• Synonyms: XCL1 / XCL2; XCL1 / XCL2 Immunizing Peptide; XCL1; chemokine (C motif) ligand 1; ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1; SCYC1; OTTHUMP00000032498; OTTHUMP00000060404; lymphotactin; region containing small inducible cytokine subfamily C; member 1 (lymphotactin); small inducible cytokine subfamily C; m; XCL1 blocking peptide

• Reactivity: Human
• Form/Format: 100ug of dried peptide
• Sequence: C-RDVVRSMDRKSNTRN
• Sequence Length: 114

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4506853
• NCBI GeneID: 6375
• NCBI Accession #: NP_002986.1; NP_003166.1
• NCBI GenBank Nucleotide #: NM_002995.2
• Molecular Weight: 12,517 Da
• NCBI Official Full Name: lymphotactin
• NCBI Official Synonym Full Names: X-C motif chemokine ligand 1
• NCBI Official Symbol: XCL1
• NCBI Official Synonym Symbols: LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• NCBI Protein Information: lymphotactin
• UniProt Protein Name: Lymphotactin
• Protein Family: Lymphotactin
• UniProt Gene Name: XCL1
• UniProt Synonym Gene Names: LTN; SCYC1
• UniProt Entry Name: XCL1_HUMAN

NCBI Description

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]

Uniprot Description

XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function: CCR chemokine receptor binding; chemokine activity; chemokine receptor binding; protein homodimerization activity

Biological Process: cell-cell signaling; G-protein coupled receptor protein signaling pathway; monocyte chemotaxis; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of T cell cytokine production; negative regulation of T-helper 1 type immune response; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of interleukin-10 production; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; regulation of inflammatory response; release of sequestered calcium ion into cytosol; response to virus; signal transduction