USP6 / TRE2 / TRE17 Blocking Peptide | USP6 blocking peptide
USP6 / TRE2 / TRE17 Immunizing Peptide
NCBI and Uniprot Product Information
Uniprot Description
USP6: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Oncoprotein; Protease
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: cytoplasm; lysosome; plasma membrane; recycling endosome
Molecular Function: calmodulin binding; cysteine-type endopeptidase activity; nucleic acid binding; protein binding; ubiquitin-specific protease activity
Biological Process: protein deubiquitination; protein modification process; ubiquitin-dependent protein catabolic process
Research Articles on USP6
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Product Notes
The USP6 usp6 (Catalog #AAA425422) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The USP6 / TRE2 / TRE17 Immunizing Peptide reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: KISPLHHLQM ECSP. It is sometimes possible for the material contained within the vial of "USP6 / TRE2 / TRE17, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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