TXNDC3 blocking peptide

TXNDC3 Immunizing Peptide

Cat. Num. AAA425549

• Gene Names: NME8; CILD6; SPTRX2; TXNDC3; NM23-H8; sptrx-2; HEL-S-99
• Reactivity: Human
• Synonyms: TXNDC3; TXNDC3 Immunizing Peptide; thioredoxin domain containing 3 (spermatozoa); CILD6; NME8; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; thioredoxin domain containing 3; thioredoxin domain-containing 3 (spermatozoa); TXNDC3 blocking peptide

• Reactivity: Human
• Form/Format: 100ug of dried peptide
• Sequence: C-TEPQTDTEPNERSE
• Sequence Length: 588

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 148839372
• NCBI GeneID: 51314
• NCBI Accession #: NP_057700.3
• NCBI GenBank Nucleotide #: NM_016616.4
• Molecular Weight: 67,270 Da
• NCBI Official Full Name: thioredoxin domain-containing protein 3
• NCBI Official Synonym Full Names: NME/NM23 family member 8
• NCBI Official Symbol: NME8
• NCBI Official Synonym Symbols: CILD6; SPTRX2; TXNDC3; NM23-H8; sptrx-2; HEL-S-99
• NCBI Protein Information: thioredoxin domain-containing protein 3
• UniProt Protein Name: Thioredoxin domain-containing protein 3
• UniProt Gene Name: NME8
• UniProt Synonym Gene Names: SPTRX2; TXNDC3; Sptrx-2
• UniProt Entry Name: TXND3_HUMAN

NCBI Description

This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]

Uniprot Description

TXNDC3: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Defects in NME8 are the cause of primary ciliary dyskinesia type 6 (CILD6). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.

Protein type: Kinase, nucleoside diphosphate; Oxidoreductase; Other group; NDK family

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cytoplasm

Molecular Function: microtubule binding; nucleoside diphosphate kinase activity

Biological Process: cell differentiation; cell redox homeostasis; cilium biogenesis; CTP biosynthetic process; GTP biosynthetic process; multicellular organismal development; nucleoside diphosphate phosphorylation; sperm motility; spermatogenesis; UTP biosynthetic process

Disease: Ciliary Dyskinesia, Primary, 6