RASSF5 blocking peptide

RASSF5 Peptide - N-terminal region

Cat. Num. AAA3248031

• Gene Names: RASSF5; RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3
• Reactivity: Human
• Synonyms: RASSF5; RASSF5 Peptide - N-terminal region; RASSF5 blocking peptide

• Reactivity: Human
• Form/Format: Lyophilized powder
• Sequence: Synthetic peptide located within the following region: IGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAR
• Sequence Length: 418

• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for RASSF5 blocking peptide

This is a synthetic peptide designed for use in combination with anti- RASSF5 Antibody, made

Target Description: This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for RASSF5 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 32996731
• NCBI GeneID: 83593
• NCBI Accession #: NP_872604.1
• NCBI GenBank Nucleotide #: NM_182663.3
• UniProt Accession #: Q8WWW0
• Molecular Weight: 45 kDa
• NCBI Official Full Name: ras association domain-containing protein 5 isoform A
• NCBI Official Synonym Full Names: Ras association domain family member 5
• NCBI Official Symbol: RASSF5
• NCBI Official Synonym Symbols: RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3
• NCBI Protein Information: ras association domain-containing protein 5
• UniProt Protein Name: Ras association domain-containing protein 5
• Protein Family: Ras association domain-containing protein
• UniProt Gene Name: RASSF5
• UniProt Synonym Gene Names: NORE1; RAPL; RAPL
• UniProt Entry Name: RASF5_HUMAN

NCBI Description

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RASSF5: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Autophagy; Tumor suppressor; Cytoskeletal

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: microtubule; cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding

Biological Process: negative regulation of cell proliferation; apoptosis; positive regulation of protein ubiquitination