ITGB2 / LFA-1 Blocking Peptide | ITGB2 blocking peptide
ITGB2 / LFA-1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Description
ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.; Cell surface
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cell surface; integrin complex; membrane; plasma membrane; receptor complex; secretory granule
Molecular Function: cell adhesion molecule binding; glycoprotein binding; ICAM-3 receptor activity; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity; protein kinase binding
Biological Process: activation of NF-kappaB transcription factor; aging; apoptosis; cell adhesion; cell-cell signaling; cell-matrix adhesion; cellular extravasation; endothelial cell migration; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; inflammatory response; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; leukocyte migration during inflammatory response; natural killer cell activation; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; receptor clustering; receptor internalization; regulation of cell shape; regulation of immune response; regulation of peptidyl-tyrosine phosphorylation; toll-like receptor 4 signaling pathway
Disease: Leukocyte Adhesion Deficiency, Type I
Research Articles on ITGB2
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Product Notes
The ITGB2 itgb2 (Catalog #AAA428532) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The ITGB2 / LFA-1 Immunizing Peptide reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-ETQEDHNG GQKQLS. It is sometimes possible for the material contained within the vial of "ITGB2 / LFA-1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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