anti-Human TMEPA Antibody | anti-TMEPA antibody

TMEPA Antibody

Cat. Num. AAA853989

• Gene Names: PMEPA1; STAG1; TMEPAI
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: TMEPA; TMEPA Antibody; Transmembrane prostate androgen-induced protein; Solid tumor-associated 1 protein; TMEPAI; PMEPA1; STAG1; anti-TMEPA antibody

• Reactivity: Human
• Specificity: TMEPA antibody detects endogenous levels of total TMEPA protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 259

• Applicable Applications for anti-TMEPA antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human TMEPA.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

(Peptide-+)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human prostate tissue using TMEPA antibody. Western blot analysis of extracts from HT-29 cells, using TMEPA antibody.)

Immunofluorescence (IF)

(Peptide-+ Immunofluorescence analysis of HUVEC cells, using TMEPA antibody.)

Product Categories/Family for anti-TMEPA antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Xu L.L., Genomics 66:257-263(2000). Rae F.K., Mol. Carcinog. 32:44-53(2001). Deloukas P., Nature 414:865-871(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 364023812
• NCBI GeneID: 56937
• NCBI Accession #: NP_001242905.1
• NCBI GenBank Nucleotide #: NM_001255976.1
• UniProt Accession #: Q969W9; Q5TDR6; Q8NER4; Q96B72; Q9UJD3
• Molecular Weight: 26,201 Da
• NCBI Official Full Name: protein TMEPAI isoform d
• NCBI Official Synonym Full Names: prostate transmembrane protein, androgen induced 1
• NCBI Official Symbol: PMEPA1
• NCBI Official Synonym Symbols: STAG1; TMEPAI
• NCBI Protein Information: protein TMEPAI
• UniProt Protein Name: Protein TMEPAI
• UniProt Gene Name: PMEPA1
• UniProt Synonym Gene Names: STAG1; TMEPAI

NCBI Description

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).