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Western Blot (WB) (Western blot analysisof Thyroglobulin expression in human thyroid tissue extract with Thyroglobulin (4A2H11).)

anti-Human Thyroglobulin Antibody | anti-TG antibody

Anti-Human Thyroglobulin Purified Ab

Gene Names
TG; TGN; AITD3
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, Immunofluorescence, Flow Cytometry, Functional Assay
Synonyms
Thyroglobulin; Anti-Human Thyroglobulin Purified Ab; anti-TG antibody
Ordering
For Research Use Only!
Reactivity
Human
Clone Number
4A2H11
Form/Format
Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide
Sequence Length
2768
Applicable Applications for anti-TG antibody
Immunohistochemistry (IHC), Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Preparation and Storage
Store at 4 degree C. DO NOT FREEZE. LIGHT SENSITIVE MATERIAL.

Western Blot (WB)

(Western blot analysisof Thyroglobulin expression in human thyroid tissue extract with Thyroglobulin (4A2H11).)

Western Blot (WB) (Western blot analysisof Thyroglobulin expression in human thyroid tissue extract with Thyroglobulin (4A2H11).)
Related Product Information for anti-TG antibody
Thyroglobulin is a large preprotein containing multiple glycosylation sites.Molecular Weight of Thyroglobulin: 305/298 kDa.Located in the thyroid gland, thyroglobulin is the precursor of the iodinated thyroid hormones thyroxine and triiodothyronine. Thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulum, prior to forming dimers. This dimerization, as well as export of thyroglobulin to the Golgi complex, has been shown to require Ca2+. Defects in thyroglobulin are known to cause some types of goiter (an enlargement of the thyroid gland). This condition is thought to result from defective dimerization and transport of thyroglobulin to the Golgi complex.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
298,383 Da
NCBI Official Full Name
thyroglobulin
NCBI Official Synonym Full Names
thyroglobulin
NCBI Official Symbol
TG
NCBI Official Synonym Symbols
TGN; AITD3
NCBI Protein Information
thyroglobulin
UniProt Protein Name
Thyroglobulin
Protein Family
UniProt Gene Name
TG
UniProt Synonym Gene Names
Tg

NCBI Description

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

Uniprot Description

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Research Articles on TG

Similar Products

Product Notes

The TG tg (Catalog #AAA8510542) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human Thyroglobulin Purified Ab reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Thyroglobulin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the TG tg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thyroglobulin, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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