anti-Human RFX2 Antibody | anti-RFX2 antibody

RFX2 Antibody

Cat. Num. AAA854656

• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: RFX2; RFX2 Antibody; DNA-binding protein RFX2; Regulatory factor X 2; anti-RFX2 antibody

• Reactivity: Human
• Specificity: RFX2 antibody detects endogenous levels of total RFX2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 723

• Applicable Applications for anti-RFX2 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:10000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human RFX2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using RFX2 antibody.)

Product Categories/Family for anti-RFX2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Reith W., Mol. Cell. Biol. 14:1230-1244(1994). Sjoeblom T., Science 314:268-274(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 19743881
• NCBI GeneID: 5990
• NCBI Accession #: NP_000626.2
• NCBI GenBank Nucleotide #: NM_000635.3
• UniProt Accession #: P48378; Q6IQ44; Q8SNA2; A8K581; B3KNC4
• Molecular Weight: 77,268 Da
• NCBI Official Full Name: DNA-binding protein RFX2 isoform a
• NCBI Official Synonym Full Names: regulatory factor X2
• NCBI Official Symbol: RFX2
• NCBI Protein Information: DNA-binding protein RFX2
• UniProt Protein Name: DNA-binding protein RFX2
• Protein Family: RFX-like DNA-binding protein
• UniProt Gene Name: RFX2

NCBI Description

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]

Uniprot Description

Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene HIST1H1T ().