anti-Human PTGER3 Antibody | anti-PTGER3 antibody

PTGER3 Antibody

Cat. Num. AAA853822

• Gene Names: PTGER3; EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III
• Reactivity: Human
• Applications: Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: PTGER3; PTGER3 Antibody; Prostanoid EP3 receptor; PGE receptor; EP3 subtype; PGE2-R; anti-PTGER3 antibody

• Reactivity: Human
• Specificity: PTGER3 antibody detects endogenous levels of total PTGER3 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 390

• Applicable Applications for anti-PTGER3 antibody: Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IF: 1:100-1:500; ELISA: 1:10000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PTGER3.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunofluorescence (IF)

(Peptide-+ Immunofluorescence analysis of LOVO cells, using PTGER3 antibody.)

Product Categories/Family for anti-PTGER3 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Adam M., FEBS Lett. 338:170-174(1994). Schmid A., Eur. J. Biochem. 228:23-30(1995). Yang J., Biochem. Biophys. Res. Commun. 198:999-1006(1994).

NCBI and Uniprot Product Information

• NCBI GI #: 186659506
• NCBI GeneID: 5733
• NCBI Accession #: NP_001119516.1
• NCBI GenBank Nucleotide #: NM_001126044.1
• UniProt Accession #: P43115; O00326; Q12943; Q12944; Q12945; Q147X8; Q16546; Q5CZ59; Q5CZ61; B0AZN4; B1AK19; B5BUP5
• Molecular Weight: 47,736 Da
• NCBI Official Full Name: prostaglandin E2 receptor EP3 subtype isoform 4
• NCBI Official Synonym Full Names: prostaglandin E receptor 3
• NCBI Official Symbol: PTGER3
• NCBI Official Synonym Symbols: EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III
• NCBI Protein Information: prostaglandin E2 receptor EP3 subtype
• UniProt Protein Name: Prostaglandin E2 receptor EP3 subtype
• Protein Family: Prostaglandin E2 receptor
• UniProt Gene Name: PTGER3
• UniProt Synonym Gene Names: PGE receptor EP3 subtype; PGE2 receptor EP3 subtype

NCBI Description

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems ().