anti-Human LILRA4 Antibody | anti-LILRA4 antibody

Goat anti-LILRA4 Antibody

Cat. Num. AAA423810

• Gene Names: LILRA4; ILT7; CD85g
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: LILRA4; Goat anti-LILRA4 Antibody; leukocyte immunoglobulin-like receptor; subfamily A (with TM domain); member 4; CD85g; ILT7; CD85 antigen-like family member G; ILT-7; immunoglobulin-like transcript 7; leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunog; anti-LILRA4 antibody

• Reactivity: Human
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Sequence Length: 499

• Applicable Applications for anti-LILRA4 antibody: Peptide ELISA (EIA), Western Blot (WB)
• Application Notes: Pep-ELISA: antibody detection limit dilution 1:1000.; WB: Approx 55kDa band observed in Human Spleen lysates. Recommended concentration: 1-3ug/ml.
• Immunogen Sequence: Peptide with sequence PRCSQEANSRKDN, from the C Terminus of the protein sequence according to NP_036408.3.
• Peptide Sequence + C: PRCSQEANSRKDN
• Epitope: C Terminus
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

((2ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 47519953
• NCBI GeneID: 23547
• NCBI Accession #: NP_036408.3
• NCBI GenBank Nucleotide #: NM_012276.3
• UniProt Accession #: P59901; Q32MC4
• Molecular Weight: 55.2kDa
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily A member 4
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A4
• NCBI Official Symbol: LILRA4
• NCBI Official Synonym Symbols: ILT7; CD85g
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 4
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 4
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRA4
• UniProt Synonym Gene Names: ILT-7

NCBI Description

This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

Uniprot Description

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca2+ (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).