anti-Human HORM1 Antibody | anti-HORM1 antibody

HORM1 Antibody

Cat. Num. AAA8509783

• Gene Names: HORMAD1; CT46; NOHMA
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: HORM1; HORM1 Antibody; HORMA domain-containing protein 1; Newborn ovary HORMA protein; Cancer/testis antigen 46; CT46; HORMAD1; NOHMA; anti-HORM1 antibody

• Reactivity: Human
• Specificity: HORM1 antibody detects endogenous levels of total HORM1 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 387

• Applicable Applications for anti-HORM1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:5000
• Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human HORM1.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, HUVEC cells and COLO cells, using HORM1 antibody.)

References

Pangas S.A., Gene Expr. Patterns 5:257-263(2004). Wiemann S., Genome Res. 11:422-435(2001). Gregory S.G., Nature 441:315-321(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 315434267
• NCBI GeneID: 84072
• NCBI Accession #: NP_001186758.1
• NCBI GenBank Nucleotide #: NM_001199829.1
• UniProt Accession #: Q86X24; Q4G114; Q5T5I3; Q5T5I4; Q5T5I5; Q6FIC1; Q9H0K8; A6NMK2; B3KUK1
• Molecular Weight: 36,676 Da
• NCBI Official Full Name: HORMA domain-containing protein 1 isoform 2
• NCBI Official Synonym Full Names: HORMA domain containing 1
• NCBI Official Symbol: HORMAD1
• NCBI Official Synonym Symbols: CT46; NOHMA
• NCBI Protein Information: HORMA domain-containing protein 1
• UniProt Protein Name: HORMA domain-containing protein 1
• UniProt Gene Name: HORMAD1
• UniProt Synonym Gene Names: CT46

NCBI Description

This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.