anti-Human GNL3L Antibody | anti-GNL3L antibody

GNL3L Antibody

Cat. Num. AAA8514819

• Gene Names: GNL3L; GNL3B
• Reactivity: Human
• Applications: Western Blot
• Purity: Immunogen affinity purified
• Synonyms: GNL3L; GNL3L Antibody; guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein; anti-GNL3L antibody

• Reactivity: Human
• Specificity: GNL3L Antibody detects endogenous levels of total GNL3L
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 582

• Applicable Applications for anti-GNL3L antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthesized peptide
• Preparation and Storage: Store at-20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, 293 cells and HT-29 cells, using GNL3L antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 296317324
• NCBI GeneID: 54552
• NCBI Accession #: NP_001171748.1
• NCBI GenBank Nucleotide #: NM_001184819.1
• UniProt Accession #: Q9NVN8
• Molecular Weight: 66 KD
• NCBI Official Full Name: guanine nucleotide-binding protein-like 3-like protein
• NCBI Official Synonym Full Names: G protein nucleolar 3 like
• NCBI Official Symbol: GNL3L
• NCBI Official Synonym Symbols: GNL3B
• NCBI Protein Information: guanine nucleotide-binding protein-like 3-like protein
• UniProt Protein Name: Guanine nucleotide-binding protein-like 3-like protein
• Protein Family: Guanine nucleotide-binding protein-like 3-like protein
• UniProt Gene Name: GNL3L

NCBI Description

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.