Rabbit anti-Human GNL3L Polyclonal Antibody | anti-GNL3L antibody

GNL3L Antibody

Cat. Num. AAA7122622

• Gene Names: GNL3L; RP11-353K22.1
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GNL3L; Polyclonal Antibody; GNL3L Antibody; Guanine Nucleotide-binding protein-like 3-like protein; anti-GNL3L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; In Phosphate Buffered Saline, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.

• Applicable Applications for anti-GNL3L antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:100-1:300; ELISA: 1:5000
• Immunogen: Synthesized peptide derived from the Internal region of human GNL3L.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western Blot analysis of HT29 cells using GNL3L Polyclonal Antibody)

Western Blot (WB)

(Western Blot analysis of NIH-3T3 LOVO cells using GNL3L Polyclonal Antibody)

Western Blot (WB)

(Western blot analysis of mouse-brain HELA KB SH-SY5Y 293T 3T3 Mouse-kidney lysis using GNL3L antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 296317324
• NCBI GeneID: 54552
• NCBI Accession #: NP_001171748.1
• NCBI GenBank Nucleotide #: NM_001184819.1
• UniProt Accession #: Q9NVN8
• Molecular Weight: 65,573 Da
• NCBI Official Full Name: guanine nucleotide-binding protein-like 3-like protein
• NCBI Official Synonym Full Names: guanine nucleotide binding protein-like 3 (nucleolar)-like
• NCBI Official Symbol: GNL3L
• NCBI Official Synonym Symbols: RP11-353K22.1
• NCBI Protein Information: guanine nucleotide-binding protein-like 3-like protein; novel GTPase
• UniProt Protein Name: Guanine nucleotide-binding protein-like 3-like protein
• Protein Family: Guanine nucleotide-binding protein-like 3-like protein
• UniProt Gene Name: GNL3L
• UniProt Entry Name: GNL3L_HUMAN

NCBI Description

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

GNL3L: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Belongs to the MMR1/HSR1 GTP-binding protein family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; nucleolus; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: metabolic process; ribosome biogenesis and assembly