anti-Human DMPK Antibody | anti-DMPK antibody

DMPK Antibody

Cat. Num. AAA854602

• Gene Names: DMPK; DM; DM1; DMK; MDPK; DM1PK; MT-PK
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: DMPK; DMPK Antibody; Myotonin-protein kinase; EC 2.7.11.1; Myotonic dystrophy protein kinase; MDPK; DM-kinase; DMK; MT-PK; anti-DMPK antibody

• Reactivity: Human
• Specificity: DMPK antibody detects endogenous levels of total DMPK protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 624

• Applicable Applications for anti-DMPK antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human DMPK.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from Jurkat cells and COLO205 cells, using DMPK antibody.)

Product Categories/Family for anti-DMPK antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Fu Y.-H., Science 255:1256-1258(1992). Shaw D.J., Genomics 18:673-679(1993). Sasagawa N., FEBS Lett. 351:22-26(1994).

NCBI and Uniprot Product Information

• NCBI GI #: 126131093
• NCBI GeneID: 1760
• NCBI Accession #: NP_001075029.1
• NCBI GenBank Nucleotide #: NM_001081560.2
• UniProt Accession #: Q09013; Q16205; Q6P5Z6; E5KR08
• Molecular Weight: 60,790 Da
• NCBI Official Full Name: myotonin-protein kinase isoform 3
• NCBI Official Synonym Full Names: DM1 protein kinase
• NCBI Official Symbol: DMPK
• NCBI Official Synonym Symbols: DM; DM1; DMK; MDPK; DM1PK; MT-PK
• NCBI Protein Information: myotonin-protein kinase
• UniProt Protein Name: Myotonin-protein kinase
• Protein Family: Myotonin-protein kinase
• UniProt Gene Name: DMPK
• UniProt Synonym Gene Names: DM1PK; MDPK; MT-PK; DMK

NCBI Description

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]

Uniprot Description

Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.