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Western Blot (WB) (Western blot analysis of extracts from HuvEc cells, using CLCNKA antibody.)

anti-Human CLCNKA Antibody | anti-CLCNKA antibody

CLCNKA Antibody

Gene Names
CLCNKA; CLCK1; ClC-K1; hClC-Ka
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
CLCNKA; CLCNKA Antibody; Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1; anti-CLCNKA antibody
Ordering
For Research Use Only!
Reactivity
Human
Specificity
CLCNKA antibody detects endogenous levels of total CLCNKA protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
686
Applicable Applications for anti-CLCNKA antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:500~1:1000
ELISA: 1:40000
Immunogen
The antiserum was produced against synthesized peptide derived from C-terminal of human CLCNKA.
Preparation and Storage
Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from HuvEc cells, using CLCNKA antibody.)

Western Blot (WB) (Western blot analysis of extracts from HuvEc cells, using CLCNKA antibody.)
References
Kieferle S., Proc. Natl. Acad. Sci. U.S.A. 91:6943-6947(1994). Gregory S.G., Nature 441:315-321(2006). Estevez R., Nature 414:558-561(2001).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
75,157 Da
NCBI Official Full Name
chloride channel protein ClC-Ka isoform 2
NCBI Official Synonym Full Names
chloride voltage-gated channel Ka
NCBI Official Symbol
CLCNKA
NCBI Official Synonym Symbols
CLCK1; ClC-K1; hClC-Ka
NCBI Protein Information
chloride channel protein ClC-Ka
UniProt Protein Name
Chloride channel protein ClC-Ka
Protein Family
UniProt Gene Name
CLCNKA
UniProt Synonym Gene Names
Chloride channel Ka

NCBI Description

This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

Research Articles on CLCNKA

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Product Notes

The CLCNKA clcnka (Catalog #AAA853930) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The CLCNKA Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CLCNKA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500~1:1000 ELISA: 1:40000. Researchers should empirically determine the suitability of the CLCNKA clcnka for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLCNKA, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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