anti-Human ADH7 Antibody | anti-ADH7 antibody

ADH7 Antibody

Cat. Num. AAA852261

• Gene Names: ADH7; ADH4
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ADH7; ADH7 Antibody; ADH-4; alcohol dehydrogenase class 4 mu/sigma; alcohol dehydrogenase class IV mu/sigma; EC 1.1.1.1; gastric alcohol dehydrogenase; retinol dehydrogenase; anti-ADH7 antibody

• Reactivity: Human
• Specificity: ADH7 antibody detects endogenous levels of total ADH7 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 386

• Applicable Applications for anti-ADH7 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human ADH7.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from COS cells, using ADH7 antibody.)

Product Categories/Family for anti-ADH7 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Satre M.A., J. Biol. Chem. 269:15606-15612(1994). Zgombic-Knight M., J. Biol. Chem. 270:4305-4311(1995). Farres J., Eur. J. Biochem. 224:549-557(1994).

NCBI and Uniprot Product Information

• NCBI GI #: 71743840
• NCBI GeneID: 131
• NCBI Accession #: NP_000664.2
• NCBI GenBank Nucleotide #: NM_000673.4
• UniProt Accession #: P40394; Q13713; A2RRB6; A8MVN9; B2R760; B4DWV6
• Molecular Weight: 42,467 Da
• NCBI Official Full Name: alcohol dehydrogenase class 4 mu/sigma chain isoform 2
• NCBI Official Synonym Full Names: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
• NCBI Official Symbol: ADH7
• NCBI Official Synonym Symbols: ADH4
• NCBI Protein Information: alcohol dehydrogenase class 4 mu/sigma chain
• UniProt Protein Name: Alcohol dehydrogenase class 4 mu/sigma chain
• Protein Family: Alcohol dehydrogenase
• UniProt Gene Name: ADH7

NCBI Description

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Description

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.MiscellaneousThere are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.CautionIt is uncertain whether Met-1 or Met-13 is the initiator.