Human KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody Pair Kit | KHDRBS1 antibody pair kit

Human KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody Pair Kit (with Standard)

Cat. Num. AAA2104302

• Gene Names: KHDRBS1; p62; p68; Sam68
• Reactivity: Human
• Applications: ELISA, ELISA
• Synonyms: KH Domain Containing; RNA Binding; Signal Transduction Associated Protein 1 (KHDRBS1); Human KH Domain Containing; Signal Transduction Associated Protein 1 (KHDRBS1) Antibody Pair Kit (with Standard); Sam68; p62; GAP-Associated Tyrosine Phosphoprotein p62; Src-associated in mitosis 68 kDa protein; p21 Ras GTPase-activating protein-associated p62; KHDRBS1 antibody pair kit

• Reactivity: Human

• Applicable Applications for KHDRBS1 antibody pair kit: ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
• Samples: Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids
• Detection Range: 31.2-2000ng/mL
• Standard: Recombinant KHDRBS1 (Lyophilized, 1 vial-10ug)
• Capture Antibody: Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
• Detection Antibody: Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)
• Producte Usage: Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
• Antibody Support Pack: Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685

Product Categories/Family for KHDRBS1 antibody pair kit

Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 119627981
• NCBI GeneID: 10657
• Molecular Weight: 44,027 Da
• NCBI Official Full Name: KH domain containing, RNA binding, signal transduction associated 1, isoform CRA_c
• NCBI Official Synonym Full Names: KH RNA binding domain containing, signal transduction associated 1
• NCBI Official Symbol: KHDRBS1
• NCBI Official Synonym Symbols: p62; p68; Sam68
• NCBI Protein Information: KH domain-containing, RNA-binding, signal transduction-associated protein 1
• UniProt Protein Name: KH domain-containing, RNA-binding, signal transduction-associated protein 1
• Protein Family: KH domain-containing, RNA-binding, signal transduction-associated protein
• UniProt Gene Name: KHDRBS1
• UniProt Synonym Gene Names: Sam68

NCBI Description

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Description

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 ().