SPHK2, full length Active Protein | SPHK2 active protein
SPHK2, Recombinant, Human, full length (Sphingosine kinase 2, SK 2)
Stability: >6 months at -80 degree C
MW 69.5kD, expressed in an Baculovirus infected Sf9 cell expression system.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
SPHK2: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, lipid; Lipid Metabolism - sphingolipid; EC 2.7.1.91
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: membrane; lysosomal membrane; cytosol
Molecular Function: D-erythro-sphingosine kinase activity; protein binding; Ras GTPase binding; sphinganine kinase activity; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity
Biological Process: blood vessel development; cell proliferation; sphingolipid metabolic process; sphingolipid biosynthetic process; positive regulation of cell proliferation; protein kinase C activation; brain development; sphinganine-1-phosphate biosynthetic process; sphingosine metabolic process; lipid phosphorylation; negative regulation of apoptosis
Research Articles on SPHK2
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Product Notes
The SPHK2 sphk2 (Catalog #AAA637900) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The SPHK2, Recombinant, Human, full length (Sphingosine kinase 2, SK 2) reacts with Human and may cross-react with other species as described in the data sheet. useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Researchers should empirically determine the suitability of the SPHK2 sphk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPHK2, full length, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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