Immunohistochemistry (IHC)
(Anti-ADRA2C antibody IHC of human artery, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit ADRA2C Polyclonal Antibody | anti-ADRA2C antibody
Rabbit Polyclonal to Human ADRA2C
Predicted Reactivity: Gorilla, Dog (at least 90% immunogen sequence identity)
Predicted Reactivity: Gorilla, Dog (at least 90% immunogen sequence identity)
Immunohistochemistry (IHC)
(Anti-ADRA2C antibody IHC of human artery, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-ADRA2C antibody IHC of human artery, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
NCBI and Uniprot Product Information
NCBI Description
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Uniprot Description
ADRA2C: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; endosome
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; alpha2-adrenergic receptor activity; epinephrine binding; alpha-2A adrenergic receptor binding
Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; activation of protein kinase B; positive regulation of vasoconstriction; energy reserve metabolic process; negative regulation of epinephrine secretion; female pregnancy; regulation of sensory perception of pain; blood coagulation; positive regulation of neuron differentiation; regulation of insulin secretion
Research Articles on ADRA2C
Similar Products
Product Notes
The ADRA2C adra2c (Catalog #AAA243609) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human ADRA2C reacts with Gibbon, Human, Monkey Predicted Reactivity: Gorilla, Dog (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's ADRA2C can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (12 ug/ml). Researchers should empirically determine the suitability of the ADRA2C adra2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADRA2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
