IL19 active protein

IL19 protein

Cat. Num. AAA537898

• Gene Names: IL19; MDA1; NG.1; ZMDA1; IL-10C
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: IL19; IL19 protein; IL-19; Melanoma differentiation association like protein protein; IL-19 protein; IL 19 protein; IL 19; Interleukin 19 protein; IL19 active protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Lyophilized from 10mM sodium citrate, pH 5.0. Reconstitute in 10 mM sodium citrate pH 3.0 to a concentration of 0.1-1.0 mg/ml.
• Sequence: Region of IL19 protein corresponding to amino acids MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA.
• Sequence Length: 177

• Applicable Applications for IL19 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: IL19 belongs to the IL10 family of regulatory cytokines which includes IL10, IL19, IL20, IL22, IL24 and IL26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL19 is a proinflammatory cytokine because it up-regulates IL6 and TNF-alpha and induces apoptosis through TNF-alpha. IL19 signals through the type I IL20R. Human and Mouse IL19 share 71% amino acid sequence identity.
• Bioactivity: Determined by its ability to activate STAT following receptor-ligand interaction.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IL19 active protein

Purified recombinant Human IL19 protein

Product Categories/Family for IL19 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 30795208
• NCBI GeneID: 29949
• NCBI Accession #: NP_037503.2
• NCBI GenBank Nucleotide #: NM_013371.3
• UniProt Accession #: Q9UHD0; Q5VUT3; Q96QR4; Q9NUA0; B6VEV9
• Molecular Weight: 17.9 kDa
• NCBI Official Full Name: interleukin-19 isoform 2
• NCBI Official Synonym Full Names: interleukin 19
• NCBI Official Symbol: IL19
• NCBI Official Synonym Symbols: MDA1; NG.1; ZMDA1; IL-10C
• NCBI Protein Information: interleukin-19
• UniProt Protein Name: Interleukin-19
• Protein Family: Interleukin
• UniProt Gene Name: IL19
• UniProt Synonym Gene Names: ZMDA1; IL-19
• UniProt Entry Name: IL19_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

IL19: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family.

Protein type: Apoptosis; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: extracellular space; extracellular region

Molecular Function: cytokine activity

Biological Process: apoptosis; positive regulation of JAK-STAT cascade; immune response; signal transduction; inflammatory response; interleukin-6 biosynthetic process