IL13 active protein

IL13 protein

Cat. Num. AAA5304536

• Gene Names: IL13; P600; IL-13
• Purity: > 98% pure; IL13 protein was purified using a a proprietary chromatographic technique.
• Synonyms: IL13; IL13 protein; IL-13 protein; MGC116788 protein; BHR1 protein; MGC116789 protein; NC30 protein; ALRH protein; IL-13; MGC116786 protein; IL 13 protein; P600 protein; IL 13; IL13 active protein

• Host: Human
• Purity/Purification: > 98% pure; IL13 protein was purified using a a proprietary chromatographic technique.
• Form/Format: Sterile filtered and lyophilized from 20 mM HCl
• Sequence Length: 81

• Protein Type: Recombinant
• Biological Significance: IL-13 is an immunoregulatory protein produced by activated T lymphocytes. The biological activities of IL-13 include the stimulation of B cell proliferation, immunoglobulin production, and induction of differentiation of B cells and monocytic lineage.
• Bioactivity: The ED50 determined by the dose-dependent stimulation of the proliferation of TF-1 cells was < 10 ng/ml, corresponding to a specific activity of > 1 x 10^6 units/mg
• Endotoxin Levels: <0.1 ng/ug
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IL13 active protein

Purified recombinant Human IL13 protein

Product Categories/Family for IL13 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 64654183
• NCBI GeneID: 3596
• Molecular Weight: 12.5 kDa
• NCBI Official Full Name: IL13 protein
• NCBI Official Synonym Full Names: interleukin 13
• NCBI Official Symbol: IL13
• NCBI Official Synonym Symbols: P600; IL-13
• NCBI Protein Information: interleukin-13
• UniProt Protein Name: Interleukin-13
• Protein Family: Interleukin
• UniProt Gene Name: IL13
• UniProt Synonym Gene Names: NC30; IL-13
• UniProt Entry Name: IL13_HUMAN

NCBI Description

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Uniprot Description

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: protein binding; interleukin-13 receptor binding; cytokine activity

Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; regulation of proton transport; microglial cell activation; response to lipopolysaccharide; signal transduction; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; positive regulation of protein secretion; cell-cell signaling; positive regulation of B cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; cell motility; inflammatory response; negative regulation of NAD(P)H oxidase activity; positive regulation of macrophage activation

Disease: Asthma, Susceptibility To; Allergic Rhinitis