FGF20 active protein

FGF20 protein

Cat. Num. AAA539567

• Gene Names: FGF20; RHDA2; FGF-20
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: FGF20; FGF20 protein; FGF-20; FGFK protein; FGF 20; FGF-20 protein; FGF 20 protein; Fibroblast Growth Factor-20 protein; FGF20 active protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: 20 mM tris-HCL, pH 7.4, with 0.1M NaCl and 1mM Benzamidine.
• Sequence: Region of FGF20 protein corresponding to amino acids PLAEVGGFLG GLEGLGQQVG SHFLLPPAGE RPPLLGERRS AAERSARGGP GAAQLAHLHG ILRRRQLYCR TGFHLQILPD GSVQGTRQDH SLFGILEFIS VAVGLVSIRG VDSGLYLGMN DKGELYGSEK LTSECIFREQ FEENWYNTYS SNIYKHGDTG RRYFVALNKD GTPRDGARSK RHQKFTHFLP RPVDPERVPE LYKDLLMYT.
• Sequence Length: 211

• Applicable Applications for FGF20 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: FGF20 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF20 signals through the FGFR 2c and 3c and is expressed during limb and brain development.
• Bioactivity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is approximately 10 ng/ml, corresponding to a specific activity of approximately 1 x 10^5 units/mg.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for FGF20 active protein

Purified recombinant Human FGF20 protein

Product Categories/Family for FGF20 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 9789947
• NCBI GeneID: 26281
• NCBI Accession #: NP_062825.1
• NCBI GenBank Nucleotide #: NM_019851.2
• UniProt Accession #: Q9NP95; B2RPH5
• Molecular Weight: 23.2 kDa
• NCBI Official Full Name: fibroblast growth factor 20
• NCBI Official Synonym Full Names: fibroblast growth factor 20
• NCBI Official Symbol: FGF20
• NCBI Official Synonym Symbols: RHDA2; FGF-20
• NCBI Protein Information: fibroblast growth factor 20
• UniProt Protein Name: Fibroblast growth factor 20
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF20
• UniProt Synonym Gene Names: FGF-20
• UniProt Entry Name: FGF20_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

Uniprot Description

FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular region

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cell-cell signaling; inner ear receptor cell differentiation; nerve growth factor receptor signaling pathway; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; regulation of cardiac muscle cell proliferation; signal transduction

Disease: Renal Hypodysplasia/aplasia 2