BD2 active protein
BD2 protein
Gene Names
DEFB4A; BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102
Applications
User optimized
Purity
> 98% pure
Synonyms
BD2; BD2 protein; BD-2; BD 2 protein; BD-2 protein; SAP1 protein; Skin-antimicrobial peptide 1 protein; BD 2; BD2 active protein
Host
Human
Purity/Purification
> 98% pure
Concentration
20ug , lyophilized (varies by lot)
Sequence
Region of BD2 protein corresponding to amino acids GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P.
Sequence Length
64
Applicable Applications for BD2 active protein
User optimized
Protein Type
Recombinant
Biological Significance
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.
Bioactivity
Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Form
Sterile filtered through a 0.2 micron filter. Lyophilized with not additives. Initially reconstitute in 10mM Acetic Acid to 0.1-1.0mg/mL. After initial reconstitution, further dilute in a buffer containing a carrier protein or stabalizer (e.g. 0.1%BSA).
Preparation and Storage
Upon receipt , store at 4°C short term, -20°C long term. Avoid repeat freeze-thaws.
Related Product Information for BD2 active protein
Purified recombinant Human BD2 protein
Product Categories/Family for BD2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
4.3 kDa
NCBI Official Full Name
beta-defensin 4A
NCBI Official Synonym Full Names
defensin, beta 4A
NCBI Official Symbol
DEFB4A
NCBI Official Synonym Symbols
BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102
NCBI Protein Information
beta-defensin 4A
UniProt Protein Name
Beta-defensin 4A
UniProt Gene Name
DEFB4A
UniProt Synonym Gene Names
DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1
UniProt Entry Name
DFB4A_HUMAN
NCBI Description
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]
Uniprot Description
defensin, beta 2: Has antibacterial activity (Potential). Belongs to the beta-defensin family. LAP/TAP subfamily.
Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: Golgi lumen; extracellular region
Biological Process: G-protein coupled receptor protein signaling pathway; defense response to bacterium; innate immune response; immune response; chemotaxis
Research Articles on BD2
Similar Products
Product Notes
The BD2 defb4a (Catalog #AAA538151) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's BD2 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the BD2 defb4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of BD2 protein correspond ing to amino acids GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P. It is sometimes possible for the material contained within the vial of "BD2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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