BD1 active protein

BD1 protein

Cat. Num. AAA539379

• Gene Names: DEFB1; BD1; HBD1; DEFB-1; DEFB101
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: BD1; BD1 protein; BD 1; BD-1 protein; BD 1 protein; BD-1; beta-Defensin 1 protein; BD1 active protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Supplied as a lyophilized powder.
• Sequence: Region of BD1 protein corresponding to amino acids DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK.
• Sequence Length: 68

• Applicable Applications for BD1 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.
• Bioactivity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for BD1 active protein

Purified recombinant Human BD1 protein

Product Categories/Family for BD1 active protein

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 4885181
• NCBI GeneID: 1672
• NCBI Accession #: NP_005209.1
• NCBI GenBank Nucleotide #: NM_005218.3
• UniProt Accession #: P60022; Q09753
• Molecular Weight: 3.9 kDa
• NCBI Official Full Name: beta-defensin 1 preproprotein
• NCBI Official Synonym Full Names: defensin, beta 1
• NCBI Official Symbol: DEFB1
• NCBI Official Synonym Symbols: BD1; HBD1; DEFB-1; DEFB101
• NCBI Protein Information: beta-defensin 1
• UniProt Protein Name: Beta-defensin 1
• UniProt Gene Name: DEFB1
• UniProt Synonym Gene Names: BD1; HBD1; BD-1; hBD-1
• UniProt Entry Name: DEFB1_HUMAN

NCBI Description

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

Uniprot Description

defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; response to bacterium; innate immune response in mucosa; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response