APRIL active protein

APRIL protein

Cat. Num. AAA539497

• Gene Names: TNFSF13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715
• Applications: User optimized
• Purity: > or = 95% pure by SDS-PAGE gel and HPLC
• Synonyms: APRIL; APRIL protein; TNFSF13 protein; TRDL-1a protein; TRDL-1 alpha protein; A Proliferating-inducing Ligand protein; APRIL active protein

• Host: Human
• Purity/Purification: > or = 95% pure by SDS-PAGE gel and HPLC
• Form/Format: Lyophilized powder from 10mM Sodium Phosphate, pH7.5 plus 500mM NaCl plus 5% Trehalose. Centrifuge the vial prior to opening. Reconstitute by adding water to a concentration of 0.1-0.5mg/ml. Do not vortex.
• Concentration: 10ug lyophilized (varies by lot)
• Sequence: Region of APRIL protein corresponding to amino acids AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL.
• Sequence Length: 205

• Applicable Applications for APRIL active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor.
• Endotoxin Levels: Endotoxin level is <0.1ng/ug of protein
• Expression System: Hi-5 cells
• Biohazard: Use appropriate laboratory precautions when handling this product.
• Preparation and Storage: Ships ambient or refrigerated. After receipt, store at 4 degree C short term, -20 degree C long term.

Related Product Information for APRIL active protein

Purified recombinant Human APRIL protein

Product Categories/Family for APRIL active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 310750389
• NCBI GeneID: 8741
• NCBI Accession #: NP_001185553.1
• NCBI GenBank Nucleotide #: NM_001198624.1
• UniProt Accession #: O75888; Q541E1; Q5U0G8; Q96HV6; Q9P1M8; Q9P1M9; A8MYD5; B4DVT2
• Molecular Weight: 16.3 kDa
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 13 isoform eta
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 13
• NCBI Official Symbol: TNFSF13
• NCBI Official Synonym Symbols: APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 13
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 13
• UniProt Gene Name: TNFSF13
• UniProt Synonym Gene Names: APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1
• UniProt Entry Name: TNF13_HUMAN

NCBI Description

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Uniprot Description

TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol; external side of plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; gene expression; signal transduction; positive regulation of isotype switching to IgA isotypes