Mouse heparan sulfate proteoglycan 2 ELISA Kit | HSPG2 elisa kit
Mouse Basement membrane-specific heparan sulfate proteoglycan core protein, HSPG2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
HSPG2: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1); a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses. Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH). The dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage.
Protein type: Cell adhesion; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; focal adhesion; extracellular region; basement membrane; basal lamina
Molecular Function: protein C-terminus binding; protein binding; protease binding; metal ion binding
Biological Process: cardiac muscle development; extracellular matrix organization and biogenesis; protein localization; chondrocyte differentiation; brain development; angiogenesis; embryonic skeletal morphogenesis; endochondral ossification
Research Articles on HSPG2
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Product Notes
The Mouse HSPG2 hspg2 (Catalog #AAA9327167) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327167 ELISA Kit recognizes Mouse HSPG2. It is sometimes possible for the material contained within the vial of "heparan sulfate proteoglycan 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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