Histamine H1 receptor (HRH1) Recombinant Protein | HRH1 recombinant protein

Recombinant Human Histamine H1 receptor (HRH1), partial

Cat. Num. AAA9423644

• Gene Names: HRH1; H1R; H1-R; HH1R; hisH1
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Histamine H1 receptor (HRH1); Recombinant Human Histamine H1 receptor (HRH1); partial; H1R; HRH1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: Tris-based buffer, 50% glycerol
• Sequence Positions: Partial, 211-416aa

• Tag Info: N-terminal 6xHis-tagged
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.

Related Product Information for HRH1 recombinant protein

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 4504491
• NCBI GeneID: 3269
• NCBI Accession #: NP_000852.1
• NCBI GenBank Nucleotide #: NM_000861.3
• UniProt Accession #: P35367; Q6P9E5; A8K047
• Molecular Weight: 27.2 kDa
• NCBI Official Full Name: histamine H1 receptor
• NCBI Official Synonym Full Names: histamine receptor H1
• NCBI Official Symbol: HRH1
• NCBI Official Synonym Symbols: H1R; H1-R; HH1R; hisH1
• NCBI Protein Information: histamine H1 receptor
• UniProt Protein Name: Histamine H1 receptor
• Protein Family: Histamine H1 receptor
• UniProt Gene Name: HRH1
• UniProt Synonym Gene Names: H1R; HH1R

NCBI Description

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

Uniprot Description

H1R: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytosol; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; histamine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; inositol phosphate-mediated signaling; positive regulation of inositol trisphosphate biosynthetic process; regulation of synaptic transmission; regulation of vasoconstriction