Beta 2 Microglobulin Protein | B2M protein

BETA 2 MICROGLOBULIN

Cat. Num. AAA319479

• Purity: > 98% Purity (SDS-PAGE); Purification by proprietary methods.
• Synonyms: Beta 2 Microglobulin; BETA 2 MICROGLOBULIN; B2M protein

• Host: Host: Human; Source: Human Urine
• Specificity: Beta 2 Microglobulin
• Purity/Purification: > 98% Purity (SDS-PAGE); Purification by proprietary methods.
• Form/Format: Purified, Liquid

• Inactivation: Not Applicable
• Buffer: 40 mM Phosphate Buffer, pH 7.2 containing 150 mM Sodium Chloride and 1 mM EDTA, Sodium Salt.
• Preservative: 0.05% Sodium Azide
• Warning: All human source materials have tested non-reactive for HIV 1, HCV, HBV by NAT, HBsAg, HCV, HIV 1 & 2 antibodies and RPR by currently approved FDA methods. No test guarantees a product to be noninfectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Preparation and Storage: Store at 2-8 degree C. DO NOT FREEZE!

Related Product Information for B2M protein

Beta 2 Microglobulin
Human Beta 2 Microglobulin

Product Categories/Family for B2M protein

Purified Proteins and Bioactive Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 4757826
• NCBI GeneID: 567
• NCBI Accession #: NP_004039.1
• NCBI GenBank Nucleotide #: NM_004048.2
• UniProt Accession #: P61769; P01884; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4
• Molecular Weight: 13,715 Da
• NCBI Official Full Name: beta-2-microglobulin
• NCBI Official Synonym Full Names: beta-2-microglobulin
• NCBI Official Symbol: B2M
• NCBI Protein Information: beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules
• UniProt Protein Name: Beta-2-microglobulin
• Protein Family: Beta-2-microglobulin
• UniProt Gene Name: B2M
• UniProt Entry Name: B2MG_HUMAN

NCBI Description

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]

Uniprot Description

Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subunit structure: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Ref.14

Subcellular location: Secreted. Note: Detected in serum and urine. Ref.16 Ref.17

Post-translational modification: Glycation of Ile-21 is observed in long-term hemodialysis patients.

Involvement in disease: Hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]: Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.33Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32

Sequence similarities: Belongs to the beta-2-microglobulin family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain.