Homer 1 recombinant protein

Homer 1, 1- 354aa, Human, His tag, E Coli

Cat. Num. AAA203314

• Gene Names: HOMER1; HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: Homer 1; 1- 354aa; Human; His tag; E Coli; Homer protein homolog 1; HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47; Homer protein homolog 1 HOMER 1A; HOMER 1B; HOMER 1C; Homer; neuronal immediate early gene; 1; HOMER1; Ves 1; ; Homer 1 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl 20% glycerol, and 1 mM DTT
• Concentration: 1.0 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITP NMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELATLKGN NAKLTAALLE STANVKQWKQ QLAAYQEEAE RLHKRVTELE CVSSQANAVH THKTELNQTI QELEETLKLK EEEIERLKQE IDNARELQEQ RDSLTQKLQE VEIRNKDLEG QLSDLEQRLE KSQNEQEAFR NNLKTLLEIL DGKIFELTEL RDNLAKLLEC S
• Sequence Length: 354

• Applicable Applications for Homer 1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for Homer 1 recombinant protein

Homer 1 (Homer protein homolog 1) belongs to Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The Homer 1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Recombinant Homer 1 protein was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for Homer 1 recombinant protein

Signal Transduction

References

Szumlinski KK., et al. (2008) Biochem Pharmacol. 75 (1):112-133.; Roche KW., et al. (1999) J Biol Chem. 274 (36):25953-7.;

NCBI and Uniprot Product Information

• NCBI GI #: 4759198
• NCBI GeneID: 9456
• NCBI Accession #: NP_004263
• NCBI GenBank Nucleotide #: NM_004272.4
• UniProt Accession #: Q86YM7; O96003; Q86YM5; B2R688
• Molecular Weight: 44.5 kDa (391 aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: homer protein homolog 1 isoform 1
• NCBI Official Synonym Full Names: homer scaffolding protein 1
• NCBI Official Symbol: HOMER1
• NCBI Official Synonym Symbols: HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
• NCBI Protein Information: homer protein homolog 1
• UniProt Protein Name: Homer protein homolog 1
• UniProt Gene Name: HOMER1
• UniProt Synonym Gene Names: SYN47; Homer-1

NCBI Description

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Uniprot Description

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.