Holliday junction recognition Recombinant Protein | HJURP recombinant protein

Recombinant Human Holliday junction recognition protein

Cat. Num. AAA9420316

• Gene Names: HJURP; FAKTS; URLC9; hFLEG1
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Holliday junction recognition; Recombinant Human Holliday junction recognition protein; 14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9; HJURP recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-748aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for HJURP recombinant protein

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents prature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

NCBI and Uniprot Product Information

• NCBI GI #: 545477999
• NCBI GeneID: 55355
• NCBI Accession #: NP_001269891.1
• NCBI GenBank Nucleotide #: NM_001282962.1
• UniProt Accession #: Q8NCD3; Q9BUT2; Q9NSL8; A8IRH5; B4DWR0; B4DZV4
• Molecular Weight: 99.4kD
• NCBI Official Full Name: Holliday junction recognition protein isoform b
• NCBI Official Synonym Full Names: Holliday junction recognition protein
• NCBI Official Symbol: HJURP
• NCBI Official Synonym Symbols: FAKTS; URLC9; hFLEG1
• NCBI Protein Information: Holliday junction recognition protein
• UniProt Protein Name: Holliday junction recognition protein
• Protein Family: Holliday junction recognition protein
• UniProt Gene Name: HJURP

Uniprot Description

HJURP: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Histone-binding; Nucleolus

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: chromosome, pericentric region; cytosol; mitochondrion; nucleolus; nucleoplasm; nucleus

Molecular Function: histone binding; identical protein binding; protein binding

Biological Process: chromosome segregation; DNA replication-independent nucleosome assembly at centromere; regulation of DNA binding; regulation of protein complex assembly