Human histidine acid phosphatase domain containing 2A ELISA Kit | HISPPD2A elisa kit
Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1, HISPPD2A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
Uniprot Description
PPIP5K1: a bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Activated when cells are exposed to hyperosmotic stress. Belongs to the histidine acid phosphatase family. VIP1 subfamily. The His_Phos_2 domain has no apparent phosphatase activity but has been shown to have cryptic polyphosphoinositide binding activity. Seven isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.4.24; EC 2.7.4.21; Phosphatase (non-protein); Kinase, other
Chromosomal Location of Human Ortholog: 15q15.3
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: inositol 1,3,4,5,6-pentakisphosphate kinase activity; acid phosphatase activity; inositol hexakisphosphate 5-kinase activity; ATP binding; diphosphoinositol-pentakisphosphate kinase activity
Biological Process: inositol phosphate metabolic process; dephosphorylation; inositol metabolic process; phosphorylation
Research Articles on HISPPD2A
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Product Notes
The Human HISPPD2A ppip5k1 (Catalog #AAA9342413) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342413 ELISA Kit recognizes Human HISPPD2A. It is sometimes possible for the material contained within the vial of "histidine acid phosphatase domain containing 2A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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