Mouse hemochromatosis ELISA Kit | HFE elisa kit

Mouse Hereditary hemochromatosis protein, HFE ELISA Kit

Cat. Num. AAA9339437

• Gene Names: Hfe; MR2
• Reactivity: Mouse
• Synonyms: hemochromatosis; Mouse Hereditary hemochromatosis protein; HFE ELISA Kit; Mouse Hereditary hemochromatosis protein (HFE) ELISA kit; HFE1; HH; HLA-H; MGC103790; MVCD7; dJ221C16.10.1; MHC class I-like protein HFE; hemochromatosis protein; hereditary hemochromatosis protein HLA-H; high Fe; HFE elisa kit

• Reactivity: Mouse

• Samples: Bovine Body Fluids And Tissue Homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 6.25ng/ml-200ng/ml
• Sensitivity: 1.0ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for HFE elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of HF (hereafter termed "analyte") in undiluted original Bovine body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 31981697
• NCBI GeneID: 15216
• NCBI Accession #: NP_034554.2
• NCBI GenBank Nucleotide #: NM_010424.4
• UniProt Accession #: P70387; Q14AQ5; Q5SZ90; Q9D754
• Molecular Weight: 40,534 Da
• NCBI Official Full Name: hereditary hemochromatosis protein homolog
• NCBI Official Synonym Full Names: hemochromatosis
• NCBI Official Symbol: Hfe
• NCBI Official Synonym Symbols: MR2
• NCBI Protein Information: hereditary hemochromatosis protein homolog
• UniProt Protein Name: Hereditary hemochromatosis protein homolog
• Protein Family: Hereditary hemochromatosis protein
• UniProt Gene Name: Hfe
• UniProt Synonym Gene Names: Mr2
• UniProt Entry Name: HFE_MOUSE

Uniprot Description

HFE: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. Defects in HFE are a cause of hemochromatosis (HFE). A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading. Defects in HFE are associated with variegate porphyria (VP). Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. VP is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease. Iron overload due to HFE mutations is a precipitating or exacerbating factor in variegate porphyria. Defects in HFE are associated with susceptibility to microvascular complications of diabetes type 7 (MVCD7). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the MHC class I family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: recycling endosome; membrane; perinuclear region of cytoplasm; apical part of cell; early endosome; integral to membrane; plasma membrane; cytoplasmic vesicle; MHC class I protein complex

Molecular Function: peptide antigen binding; antigen binding; receptor binding

Biological Process: antigen processing and presentation; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; immune system process; positive regulation of T cell mediated cytotoxicity; immune response; hormone biosynthetic process

Disease: Alzheimer Disease