IL20RB/IL-20R2 Active Protein | IL20RB active protein

Human CellExp IL20RB / IL-20R2, human recombinant

Cat. Num. AAA845182

• Gene Names: IL20RB; DIRS1; FNDC6; IL-20R2
• Applications: SDS-Page
• Purity: >=90%
• Synonyms: IL20RB/IL-20R2; Human CellExp IL20RB / IL-20R2; human recombinant; IL20RB; IL-20R2; IL-20R-beta; DIRS1; FNDC6; IL20RB active protein

• Host: HEK293 cells
• Purity/Purification: >=90%
• Form/Format: Lyophilized from 0.22 mum filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.; Appearance: Lyophilized
• Sequence Length: 311

• Applicable Applications for IL20RB active protein: SDS-PAGE
• Solubility/Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.
• Endotoxin Level: <1 EU/mug by LAL method
• Biological Activity: Measured by its binding ability in a functional ELISA. When Recombinant Human IL?19 protein is present at 0.2 ug/mL, the concentration of rhIL20RB Fc Chimera that produces 50% of the optimal binding response is approximately 5?50 ng/ml.
• Results: Measured by its binding ability in a functional ELISA. When Recombinant Human IL?19 protein is present at 0.2 ug/mL, the concentration of rhIL20RB Fc Chimera that produces 50% of the optimal binding response is approximately 5?50 ng/ml.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for IL20RB active protein

Background: Interleukin-20 receptor subunit beta (IL20RB) is also known as IL-20R2, DIRS1, which belongs to the type II cytokine receptor family. IL20RB / IL-20R2 contains two fibronectin type-III domains. IL20RB / IL-20R2 is widely expressed with highest levels in skin and testis. IL20RB can be fused with IL20RA or IL22RA1 forming heterodimer. The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Product Categories/Family for IL20RB active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; InterleukinsProteins and Enzymes; Cytokines; Growth

NCBI and Uniprot Product Information

• NCBI GI #: 40255073
• NCBI GeneID: 53833
• NCBI Accession #: NP_653318.2
• NCBI GenBank Nucleotide #: NM_144717.3
• UniProt Accession #: Q6UXL0; Q6P438; Q8IYY5; Q8TAJ7; B4DL40
• Molecular Weight: This protein fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 49.1 kDa. The predicted N-terminus is Asp 30. As a result of glycosylation, DTT-reduced Protein migrates as 50 kDa and non-reduced protein migrates as 100 kDa.
• NCBI Official Full Name: interleukin-20 receptor subunit beta
• NCBI Official Synonym Full Names: interleukin 20 receptor beta
• NCBI Official Symbol: IL20RB
• NCBI Official Synonym Symbols: DIRS1; FNDC6; IL-20R2
• NCBI Protein Information: interleukin-20 receptor subunit beta
• UniProt Protein Name: Interleukin-20 receptor subunit beta
• Protein Family: Interleukin-20 receptor
• UniProt Gene Name: IL20RB
• UniProt Synonym Gene Names: DIRS1; IL-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6
• UniProt Entry Name: I20RB_HUMAN

NCBI Description

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

Uniprot Description

IL20RB: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-20 binding

Biological Process: positive regulation of interleukin-4 production; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; immune response-inhibiting signal transduction; homeostasis of number of cells within a tissue; negative regulation of interferon-gamma production; cytokine and chemokine mediated signaling pathway; negative regulation of type IV hypersensitivity; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production