CD112 (PRR2) Active Protein | CD112 active protein

Human CD112 Recombinant (PRR2)

Cat. Num. AAA553012

• Purity: >95%, as determined by SDS-PAGE and HPLC
• Synonyms: CD112 (PRR2); Human CD112 Recombinant (PRR2); Human CD112 Recombinant (PRR2) ; PVRL2; HVEB; PRR2; CD112; PVRR2; cd-112; CD112 active protein

• Host: HEk293 Cells
• Purity/Purification: >95%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant CD112 is supplied as a 0.2 um filtered PBS solution, pH7.2.
• Sequence Length: 538

• Biological Activity: The activity of Recombinant human CD112 was measured in a functional ELISA assay, immobilized recombinant human CD112 at 20 ug/ml (100ul/well) can bind biotinylated DNAM1 with a linear range of 0.08 - 3 ug/ml
• Domain: Ig-like C2
• Host Note: Optimized DNA sequence encoding Human extracellular domain of human CD112 including a C-terminal 6His tag was expressed in HEK293 cells.
• Molecular Weight Note: Recombinant CD112 is a monomer protein consisting of 335 amino acid residue subunits, due to glycosylation migrates as an approximately 48 kDa protein on SDS-PAGE.
• Preparation and Storage: Recombinant CD112, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.; ; Avoid repeated freeze/thaw cycles.

Related Product Information for CD112 active protein

Nectins are a small family of Ca++independent immunoglobulin (Ig) like cell adhesion molecules (CAMs) that control cell adhesion, proliferation, and migration.Nectin2 is a 60 or 65 kDa type I TM glycoprotein that is found on a variety of cell types. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), but not HSV1. It does not bind poliovirus. As a cell adhesion molecule, Nectin2 will form cishomodimers, followed by transdimers

Product Categories/Family for CD112 active protein

Receptors CD

References

• mast cell costimulation by cd226/CD112 (dnam-1/nectin-2) : a novel interface in the allergic process .J. Biol. Chem., Sep 2006; 281: 27190 - 27196.
• expression of the dnam-1 ligands, nectin-2 (CD112) and poliovirus receptor (cd155), on dendritic cells: relevance for natural killer-dendritic cell interaction .Blood, Mar 2006; 107: 2030 - 2036.
• analysis of the receptor-ligand interactions in the natural killer–mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the poliovirus receptor (cd155) and nectin-2 (CD112) .Blood, Mar 2005; 105: 2066 - 2073.
• functional characterization of dnam-1 (cd226) interaction with its ligands pvr (cd155) and nectin-2 (prr-2/CD112) .Int. Immunol., Apr 2004; 16: 533 - 538.