IL-12p40 active protein
Mouse IL-12p40
Gene Names
Il12b; p40; Il-12b; Il12p40; Il-12p40
Reactivity
Mouse
Purity
> 95% by SDS-PAGE & HPLC analyses
Synonyms
IL-12p40; Mouse IL-12p40; Interleukin-12; NKSF; CTL Maturation Factor (TCMF); Cytotoxic Lymphocyte Maturation Factor (CLMF);TSF;; p40:Interleukin-12 subunit beta; IL-12 subunit p40; IL-12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit(CLMF p40); NK cell Stimulating Factor Chain 2; IL-12p40 active protein
Host
HEK 293 cells
Reactivity
Mouse
Purity/Purification
> 95% by SDS-PAGE & HPLC analyses
Form/Format
Lyophilized
Sequence
MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGV IGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW S TEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSS PDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TL PIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVE VS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFL VEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
Sequence Length
335
Biological Activity
Determined by its ability to inhibit the proliferative effect of 2 ng/ml mIL-12p70 in T-cell enriched PBMCs.
Related Product Information for IL-12p40 active protein
IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-gamma-producing Th1 cells. Recombinant Murine IL-12p40 is a 40.0 kDa protein consisting of 313 amino acid residues and less than 5%of the IL-12p80 dimer.
Product Categories/Family for IL-12p40 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,235 Da
NCBI Official Full Name
interleukin-12 subunit beta
NCBI Official Synonym Full Names
interleukin 12b
NCBI Official Symbol
Il12b
NCBI Official Synonym Symbols
p40; Il-12b; Il12p40; Il-12p40
NCBI Protein Information
interleukin-12 subunit beta
UniProt Protein Name
Interleukin-12 subunit beta
UniProt Gene Name
Il12b
UniProt Synonym Gene Names
IL-12B; CLMF p40
NCBI Description
This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]
Uniprot Description
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Research Articles on IL-12p40
Similar Products
Product Notes
The IL-12p40 il12b (Catalog #AAA692489) is an Active Protein produced from HEK 293 cells and is intended for research purposes only. The product is available for immediate purchase. The Mouse IL-12p40 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGV IGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW S TEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSS PDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TL PIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVE VS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFL VEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS. It is sometimes possible for the material contained within the vial of "IL-12p40, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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