Oncostatin M (OSM) Active Protein | OSM active protein

Human Oncostatin M (196aa) (OSM)

Cat. Num. AAA692492

• Reactivity: Human
• Purity: >95% by SDS-PAGE and HPLC analyses
• Synonyms: Oncostatin M (OSM); Human Oncostatin M (196aa) (OSM); OSM; OSM active protein

• Host: HEK 293 cells
• Reactivity: Human
• Purity/Purification: >95% by SDS-PAGE and HPLC analyses
• Form/Format: Lyophilized
• Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLR EHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ R LPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDT AEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GR VFSKWGES PNRSRR
• Sequence Length: 231

• Biological Activity: Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is 2.0 ng/ml, corresponding to a specific activity of 5 x 105 units/mg.
• Chromosomal Location: 22q12.2

Related Product Information for OSM active protein

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6,GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide, and generates the mature OSM form. PeproTech\'s Recombinant Human Oncostatin M (196 a.a.) is as HEK293 cell-derived, 196 amino-acid length glycoprotein that has a calculated theoretical molecular weight of 22.2 kDa, but migrates at an apparent molecular weight of 32-34kDa by SDS-PAGE analysis under reducing conditions due to glycosylation.

Product Categories/Family for OSM active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 982742417
• NCBI GeneID: 5008
• NCBI Accession #: NP_001306037.1
• NCBI GenBank Nucleotide #: NM_001319108.1
• UniProt Accession #: P13725; Q6FHP8; Q9UCP6
• Molecular Weight: 28,484 Da
• NCBI Official Full Name: oncostatin-M isoform 2
• NCBI Official Synonym Full Names: oncostatin M
• NCBI Official Symbol: OSM
• NCBI Protein Information: oncostatin-M
• UniProt Protein Name: Oncostatin-M
• Protein Family: Oncostatin
• UniProt Gene Name: OSM
• UniProt Synonym Gene Names: OSM

NCBI Description

This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration ().