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Interleukin 6 Receptor Active Protein | IL6R active protein

Interleukin 6 Receptor, Recombinant, Human (IL-6R)

Gene Names
IL6R; gp80; CD126; IL6RA; IL-6RA; IL-6R-1; MGC104991
Purity
Highly Purified
> or = 98% by SDS-PAGE and HPLC analyses
Synonyms
Interleukin 6 Receptor; Recombinant; Human (IL-6R); IL6R active protein
Ordering
For Research Use Only!
Host
HEK 293 cells
Purity/Purification
Highly Purified
> or = 98% by SDS-PAGE and HPLC analyses
Form/Format
Supplied as a lyophilized powder from PBS, pH 7.2
Endotoxin Level
< or = 0.1ng/ug (1EU/ug)
Reconstitution
Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml.
Biological Activity
The ED50 as determined by its' ability to intensify the IL-6induced groth inhibition of murin M1 cells is
Country of Origin
USA
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for IL6R active protein
The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6kD protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).
Product Categories/Family for IL6R active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
37.6kD
NCBI Official Full Name
interleukin-6-receptor
NCBI Official Synonym Full Names
interleukin 6 receptor
NCBI Official Symbol
IL6R
NCBI Official Synonym Symbols
gp80; CD126; IL6RA; IL-6RA; IL-6R-1; MGC104991
NCBI Protein Information
interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; OTTHUMP00000034320; OTTHUMP00000217867; OTTHUMP00000217870; membrane glycoprotein 80; IL-6 receptor subunit alpha
UniProt Protein Name
Interleukin-6 receptor subunit alpha
Protein Family
UniProt Gene Name
IL6R
UniProt Entry Name
IL6RA_HUMAN

NCBI Description

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Uniprot Description

Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Ref.13 Ref.14Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Ref.13 Ref.14

Subunit structure: Hexamer of two molecules each of IL6, IL6R and IL6ST.

Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein Ref.11 Ref.14. Isoform 2: Secreted Ref.11 Ref.14.

Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Post-translational modification: A short soluble form may also be released from the membrane by proteolysis.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 3 subfamily.Contains 1 fibronectin type-III domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Research Articles on IL6R

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Product Notes

The IL6R il6r (Catalog #AAA650728) is an Active Protein produced from HEK 293 cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Interleukin 6 Receptor, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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