Gene Sequencing (Extract)
Histone Deacetylase 6 (HDAC6) Recombinant Protein | HDAC6 recombinant protein
Recombinant Histone Deacetylase 6 (HDAC6)
Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Gene Sequencing (Extract)
Gene Sequencing (Extract)
SDS-Page
SDS-Page
NCBI and Uniprot Product Information
Accurate Molecular Mass: 30kDa as determined by SDS-PAGE reducing conditions.
Uniprot Description
HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily.
Protein type: Ubiquitin conjugating system; EC 3.5.1.98; Deacetylase; Nuclear receptor co-regulator
Cellular Component: centrosome; microtubule; protein complex; histone deacetylase complex; leading edge; dendrite; perikaryon; inclusion body; caveola; cytosol; nucleoplasm; dynein complex; microtubule associated complex; cell projection; perinuclear region of cytoplasm; axon; cytoplasmic microtubule; cytoplasm; nucleus
Molecular Function: ubiquitin binding; hydrolase activity; zinc ion binding; metal ion binding; histone deacetylase binding; microtubule binding; beta-catenin binding; beta-tubulin binding; Hsp90 protein binding; misfolded protein binding; actin binding; histone deacetylase activity (H3-K9 specific); histone deacetylase activity (H3-K14 specific); protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); tubulin deacetylase activity; ubiquitin protein ligase binding; NAD-dependent histone deacetylase activity (H4-K16 specific); polyubiquitin binding; histone deacetylase activity; tau protein binding; alpha-tubulin binding
Biological Process: negative regulation of proteolysis; ubiquitin-dependent protein catabolic process; response to misfolded protein; protein polyubiquitination; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; positive regulation of signal transduction; regulation of fat cell differentiation; macroautophagy; negative regulation of microtubule depolymerization; response to toxin; misfolded or incompletely synthesized protein catabolic process; histone deacetylation; chromatin modification; regulation of gene expression, epigenetic; response to organic substance; intracellular protein transport; protein complex disassembly; regulation of transcription, DNA-dependent; protein amino acid deacetylation; lysosome localization; regulation of receptor activity; negative regulation of protein complex disassembly
Research Articles on HDAC6
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Product Notes
The HDAC6 hdac6 (Catalog #AAA2011657) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Histone Deacetylase 6 (HDAC6) reacts with Mus musculus (Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's Histone Deacetylase 6 (HDAC6) can be used in a range of immunoassay formats including, but not limited to, Positive Control, Immunogen, SDS-PAGE, Western Blot (WB). Researchers should empirically determine the suitability of the HDAC6 hdac6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: R EGANFDSIYI CPSTFACAKL ATGAACRLVE AVLSGEVLNG IAVVRPPGHH AEPNAACGFC FFNSVAVAAR HAQIIAGRAL RILIVDWDVH HGNGTQHIFE DDPSVLYVSL HRYDRGTFFP MGDEGASSQV GRDAGIGFTV NVPWNGPRMG DADYLAAWHR LVLPIAYEFN PELVLISAGF DAAQGDPLGG CQVTPEGYAH LTHLLMGLAG GRIILILEGG YNLASISESM AACTHSLLGD PPPQLTLLRP P. It is sometimes possible for the material contained within the vial of "Histone Deacetylase 6 (HDAC6), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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