SDS-Page
(Figure 1. Human TIM3 Protein, mFc-His Tag on SDS-PAGE under reducing condition.)
TIM3 recombinant protein
Recombinant human TIM3 protein with C-terminal mouse Fc and 6xHis tag
Shipping: Blue Ice
SDS-Page
(Figure 1. Human TIM3 Protein, mFc-His Tag on SDS-PAGE under reducing condition.)
SDS-Page
(Figure 1. Human TIM3 Protein, mFc-His Tag on SDS-PAGE under reducing condition.)
ELISA (EIA)
(Figure 2. ELISA plate pre-coated by 2 ug/ml (100 ul/well) Human TIM3, mFc-His tagged protein can bind Anti-TIM3 Neutralizingantibody in a linear range of 0.12-6.89 ng/ml.)
ELISA (EIA)
(Figure 2. ELISA plate pre-coated by 2 ug/ml (100 ul/well) Human TIM3, mFc-His tagged protein can bind Anti-TIM3 Neutralizingantibody in a linear range of 0.12-6.89 ng/ml.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Uniprot Description
TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component: integral to membrane
Disease: Rheumatoid Arthritis
Research Articles on TIM3
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Product Notes
The TIM3 havcr2 (Catalog #AAA188086) is a Recombinant Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TIM3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the TIM3 havcr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: TIM3(Ser22 -Gly202)+m Fc(Pro99-L ys330). It is sometimes possible for the material contained within the vial of "TIM3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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