Hepatitis A virus cellular receptor 2 (HAVCR2) Recombinant Protein | HAVCR2 recombinant protein

Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial

Cat. Num. AAA9018627

• Gene Names: HAVCR2; TIM3; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Hepatitis A virus cellular receptor 2 (HAVCR2); Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2); partial; T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3)(T-cell immunoglobulin mucin receptor 3)(TIM-3)(T-cell membrane protein 3); HAVCR2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 20-200aa, Partial
• Sequence: RSSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIR

• Species: Homo sapiens (Human)
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Product Categories/Family for HAVCR2 recombinant protein

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 311033536
• NCBI GeneID: 84868
• UniProt Accession #: Q8TDQ0; Q8WW60; Q96K94; B2RAY2
• Molecular Weight: 301
• NCBI Official Full Name: Hepatitis A virus cellular receptor 2
• NCBI Official Synonym Full Names: hepatitis A virus cellular receptor 2
• NCBI Official Symbol: HAVCR2
• NCBI Official Synonym Symbols: TIM3; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
• NCBI Protein Information: hepatitis A virus cellular receptor 2; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin mucin receptor 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglo
• UniProt Protein Name: Hepatitis A virus cellular receptor 2
• Protein Family: Hepatitis A virus cellular receptor
• UniProt Gene Name: HAVCR2
• UniProt Synonym Gene Names: TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3
• UniProt Entry Name: HAVR2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Uniprot Description

TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to membrane

Disease: Rheumatoid Arthritis