Hemagglutinin (HA) Recombinant Protein | HA recombinant protein

Recombinant Influenza A virus (A/Shanghai/02/2013 (H7N9)) Hemagglutinin (HA), partial

Cat. Num. AAA7103021

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Hemagglutinin (HA); Recombinant Influenza A virus (A/Shanghai/02/2013 (H7N9)) Hemagglutinin (HA); partial; HA recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 19-524aa; Partial
• Sequence: DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQSFVPSPGARPQVNGLSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQRSLLLATGMKNVPEIPKGRGLFGAIAGFIENGWEGLIDGWYGFRHQNAQGEGTAADYKSTQSAIDQITGKLNRLIEKTNQQFELIDNEFNEVEKQIGNVINWTRDSITEVWSYNAELLVAMENQHTIDLADSEMDKLYERVKRQLRENAEEDGTGCFEIFHKCDDDCMASIRNNTYDHSKYREEAMQNRIQIDPVKLSSGYKDV
• Sequence Length: 560

• Species: Influenza A virus (A/chicken/Jiangsu/1021/2013(H7N9))
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.

SDS-PAGE

Related Product Information for HA recombinant protein

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the mbrane of the endocytosed virus particle with the endosomal mbrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

References

Detection of the Avian Influenza A (H7N9) Virus by Real-Time RT-PCR Assays in Taizhou City, China, April to May 2013.Young N.Z., Pei Z., Wang Y., Zhou W., Lu K., Kong W.

NCBI and Uniprot Product Information

• NCBI GI #: 752901097
• NCBI GeneID: 23104227
• NCBI Accession #: YP_009118475.1
• NCBI GenBank Nucleotide #: NC_026425.1
• UniProt Accession #: R4NN21
• Molecular Weight: 72.2 kDa
• NCBI Official Full Name: hemagglutinin
• NCBI Official Symbol: HA
• NCBI Protein Information: hemagglutinin; HA1; HA2
• UniProt Protein Name: Hemagglutinin
• Protein Family: Hemagglutinin
• UniProt Gene Name: HA

Uniprot Description

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.