Hemagglutinin-Influenza A Virus H3N2 Perth 16/09 Recombinant Protein | HA recombinant protein

Recombinant Hemagglutinin-Influenza A Virus H3N2 Perth 16/09

Cat. Num. AAA144822

• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Hemagglutinin-Influenza A Virus H3N2 Perth 16/09; Recombinant Hemagglutinin-Influenza A Virus H3N2 Perth 16/09; Perth 16/09; Hemagglutinin-Influenza A Virus H3N2 Perth 16/09 Recombinant; HA recombinant protein

• Host: Baculovirus
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The H3N2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.; Sterile Filtered colorless solution.
• Sequence: ADPMQKLPGN DNSTATLCLG HHAVPNGTIV KTITNDQIEV TNATELVQSS STGEICDSPH QILDGKNCTL IDALLGDPQC DGFQNKKWDL FVERSKAYSN CYPYDVPDYA SLRSLVASSG TLEFNNESFN WTGVTQNGTS SACIRRSKNS FFSRLNWLTH LNFKYPALNV TMPNNEQFDK LYIWGVHHPG TDKDQIFLYA QASGRITVST KRSQQTVSPN IGSRPRVRNI PSRISIYWTI VKPGDILLIN STGNLIAPRG YFKIRSGKSS IMRSDAPIGK CNSECITPNG SIPNDKPFQN VNRITYGACP RYVKQNTLKL ATGMRNVPEK QTRHHHHHH.
• Sequence Length: 566

Related Product Information for HA recombinant protein

Description: H3N2 produced in Hi-5 cell of Baculovirus is a single polypeptide chain containing 339 amino acids (17-345) and having a molecular mass of 37.8kDa.H3N2 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

Introduction: H3N2 is a subtype of the influenza A virus. Its name derives from the forms of the two kinds of proteins on the surface of its coat, hemagglutinin (H) and neuraminidase (N). H3N2 exchanges genes for internal proteins with other influenza subtypes. H3N2 has tended to dominate in prevalence over H1N1, H1N2, and influenza B. H3N2 strain descended from H2N2 by antigenic shift, in which genes from multiple subtypes re-assorted to form a new virus. Both the H2N2 and H3N2 strains contained genes from avian influenza viruses.H3N2 viruses are able to infect mammals and birds. In pigs, humans, and birds, the virus has mutated into many strains. Hemagglutinin(HA) binds to sialic acid-containing receptors on the cell surface, generating the attachment of the virus particle to the cell. HA has a vital part in the determination of host range restriction and virulence and is in charge of the diffusion of the virus into the cell cytoplasm by facilitating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.

Product Categories/Family for HA recombinant protein

Viral Antigens; INFLUENZA VIRUS; Viral Antigens; Influenza

NCBI and Uniprot Product Information

• UniProt Accession #: C6KNH7
• Molecular Weight: 63,641 Da
• UniProt Protein Name: Hemagglutinin
• Protein Family: Hemagglutinin
• UniProt Gene Name: HA
• UniProt Entry Name: C6KNH7_9INFA

Uniprot Description

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.