Guinea Pig Sodium/potassium/calcium exchanger 1 (SLC24A1) ELISA Kit | SLC24A1 elisa kit
Guinea pig Sodium/potassium/calcium exchanger 1 (SLC24A1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
SLC24A1: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Defects in SLC24A1 are the cause of congenital stationary night blindness type 1D (CSNB1D). An autosomal recessive form of congenital stationary night blindness a non- progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus. Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: membrane; outer membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; calcium, potassium:sodium antiporter activity; symporter activity
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; visual perception; transport; calcium ion transport; response to light intensity; ion transport; transmembrane transport
Disease: Night Blindness, Congenital Stationary, Type 1d
Research Articles on SLC24A1
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Product Notes
The Guinea Pig SLC24A1 slc24a1 (Catalog #AAA7224574) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7224574 ELISA Kit recognizes Guinea Pig SLC24A1. It is sometimes possible for the material contained within the vial of "Sodium/potassium/calcium exchanger 1 (SLC24A1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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