Mouse IGFBP2 Monoclonal Antibody | anti-IGFBP2 antibody

Mouse monoclonal IGFBP2 antibody

Cat. Num. AAA5306448

• Gene Names: IGFBP2; IBP2; IGF-BP53
• Applications: Flow Cytometry, Functional Assay, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: IGFBP2; Monoclonal Antibody; Mouse monoclonal IGFBP2 antibody; IGFBP2 antibody; anti-IGFBP2 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 1A7
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5-1 mg/ml (varies by lot)
• Sequence Length: 159

• Applicable Applications for anti-IGFBP2 antibody: Flow Cytometry (FC/FACS), Western Blot (WB)
• Application Notes: FC: 1:100; WB: 1:1000
• Immunogen: IGFBP2 antibody was raised in Mouse using full length human recombinant protein of human IGFBP2 produced in HEK293T cell as the immunogen.
• Cross-Reactivity: Human
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Flow Cytometry (FC/FACS)

(Flow Cytometric analysis of HEK293T cells transfected with either recombinant IGFBP2 protein (red) or empty vector (blue) stained using IGFBP2 antibody)

Product Categories/Family for anti-IGFBP2 antibody

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 929524276
• NCBI GeneID: 3485
• NCBI Accession #: NP_001300921.1
• NCBI GenBank Nucleotide #: NM_001313992.1
• UniProt Accession #: P18065; Q14619; Q9UCL3
• Molecular Weight: 34,814 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein 2 isoform c
• NCBI Official Synonym Full Names: insulin like growth factor binding protein 2
• NCBI Official Symbol: IGFBP2
• NCBI Official Synonym Symbols: IBP2; IGF-BP53
• NCBI Protein Information: insulin-like growth factor-binding protein 2
• UniProt Protein Name: Insulin-like growth factor-binding protein 2
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: IGFBP2
• UniProt Synonym Gene Names: BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2

NCBI Description

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

IGFBP2: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: extracellular region; extracellular space

Molecular Function: insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; receptor binding

Biological Process: cellular protein metabolic process; positive regulation of activated T cell proliferation; regulation of insulin-like growth factor receptor signaling pathway