Guinea Pig Potassium voltage-gated channel subfamily H member 2 (KCNH2) ELISA Kit | KCNH2 elisa kit
Guinea pig Potassium voltage-gated channel subfamily H member 2 (KCNH2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv11.1: the ether-a-go-go related gene is a pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel is associated with cardiac arrhythmias and rhythmic excitability of the pituitary. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with Kv11.2 and Kv11.3. Interacts with ALG10B. Heteromultimer with KCNE1 and KCNE2. Defects in Kv11.1 are the cause of long QT syndrome type 2 (LQT2), a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. Defects in Kv11.1 are the cause of short QT syndrome type 1 (SQT1), a heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. Four isoforms of the human protein are produced by alternative splicing. Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: voltage-gated potassium channel complex; cell surface; cytoplasm; plasma membrane; nuclear envelope
Molecular Function: identical protein binding; protein binding; voltage-gated potassium channel activity; protein homodimerization activity; delayed rectifier potassium channel activity; ubiquitin protein ligase binding; inward rectifier potassium channel activity; two-component sensor activity
Biological Process: synaptic transmission; regulation of membrane potential; two-component signal transduction system (phosphorelay); regulation of the rate of heart contraction by hormone; potassium ion homeostasis; cardiac muscle contraction
Disease: Long Qt Syndrome 2; Short Qt Syndrome 1
Research Articles on KCNH2
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Product Notes
The Guinea Pig KCNH2 kcnh2 (Catalog #AAA7208050) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7208050 ELISA Kit recognizes Guinea Pig KCNH2. It is sometimes possible for the material contained within the vial of "Potassium voltage-gated channel subfamily H member 2 (KCNH2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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