Guinea Pig hosphoenolpyruvate Carboxykinase 1, Soluble (PCK1) ELISA Kit | PCK1 elisa kit
Guinea pig hosphoenolpyruvate Carboxykinase 1, Soluble (PCK1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
PCK1: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Defects in PCK1 are the cause of cytosolic phosphoenolpyruvate carboxykinase deficiency (C-PEPCKD). A metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autoposy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
Protein type: Carbohydrate Metabolism - pyruvate; Lyase; Kinase, other; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.1.1.32; Carbohydrate Metabolism - citrate (TCA) cycle
Chromosomal Location of Human Ortholog: 20q13.31
Cellular Component: cytoplasm; cytosol
Molecular Function: GDP binding; GTP binding; carboxylic acid binding; phosphoenolpyruvate carboxykinase (GTP) activity; manganese ion binding; magnesium ion binding
Biological Process: oxaloacetate metabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis; response to activity; glycerol biosynthetic process from pyruvate; drug metabolic process; internal protein amino acid acetylation; glucose homeostasis; gluconeogenesis; response to insulin stimulus
Disease: Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic
Research Articles on PCK1
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Product Notes
The Guinea Pig PCK1 pck1 (Catalog #AAA265754) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA265754 ELISA Kit recognizes Guinea Pig PCK1. It is sometimes possible for the material contained within the vial of "hosphoenolpyruvate Carboxykinase 1, Soluble (PCK1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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