Guinea Pig Cryptochrome-2 (CRY2) ELISA Kit | CRY2 elisa kit
Guinea pig Cryptochrome-2 (CRY2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Uniprot Description
CRY2: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. Belongs to the DNA photolyase class-1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Lyase
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: cytoplasm; extracellular region; nucleus
Molecular Function: protein binding; ubiquitin binding; DNA binding; DNA (6-4) photolyase activity; deoxyribodipyrimidine photo-lyase activity; damaged DNA binding; blue light photoreceptor activity; single-stranded DNA binding; phosphatase binding
Biological Process: photoreactive repair; circadian rhythm; blue light signaling pathway; transcription, DNA-dependent; negative regulation of phosphoprotein phosphatase activity; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; glucose homeostasis; negative regulation of transcription, DNA-dependent; protein-chromophore linkage; entrainment of circadian clock by photoperiod
Research Articles on CRY2
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Product Notes
The Guinea Pig CRY2 cry2 (Catalog #AAA7202051) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7202051 ELISA Kit recognizes Guinea Pig CRY2. It is sometimes possible for the material contained within the vial of "Cryptochrome-2 (CRY2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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